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EC number: 469-300-0 | CAS number: 63675-73-0
This study was conducted in compliance with Method B1 tris of Commission Directive 2004/73/EC and OECD Guidelines for Testing of Chemicals, Method 423 (adopted 17 Dec 2001).
This study was conducted to assess the acute toxicity of the test article, BetaKetosulfide following a single oral administration to small groups of rats. The study design provides information for hazard assessmentand classification and enables a chemical to be assigned to toxicity classes but severely restricts animal usage.
Groups of three female fasted rats were given the test article as a single dose on Day1 by oral gavage at a dose level of 2000mg/kg. The test article was dispersed in 1% aqueous methyl cellulose and administered at a dose volume of10mg/kg. All animals were killed on Day 15 and subsequently underwent a full necropsy.
There were no deaths following a single oral dose of Beta Ketosulfide among rats dosed at 2000mg/kg. Piloerection was observed in all three animals in the first group at 2,3 and 4 hours post dose. No other clinical signs were noted.
All rats achieved body weight gains during the first and second weeks of the study. No abnormalities were noted at necrospsy. The acute median lethal oral dose level of the test article, BetaKetosulfide, was found to exceed 2000mg/kg.
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