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EC number: 223-151-6
CAS number: 3749-87-9
article reviewed the pharmacokinetics of chenodeoycholic acid and of
ursodeoxycholic acid. Ursodeoxycholic acid is not well absorbed by the
gastrointestinal tract. It is efficiently extracted by the liver, where
it is conjugated with glycerine and taurine and then secreted in the
bile. Afterwards it undergo into the enterohepatic circulation
(resulting in low serum concentrations) together with the other bile
salts and, despite the rapid hepatic extraction, the clearance of the
substance is low because of the enterohepatic recirculation. The
elimination of ursodeoxycholic acid, unmodified or after bacterial
biotrasformation to lithocholic acid, occurs mainly by feces.
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