Methyl 3-α,7-α-diacetoxy-12-α-hydroxy-5-β-cholan-24-oate

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The study has been carried out accordin to OECD testing guidelines.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Deviations:

no

GLP compliance:

no

Type of method:

shake-flask method to: flask method

Partition coefficient type:

octanol-water

Test material

Test material information

Constituent 1

Reference substance name:

Ursodeoxycholic acid

EC Number:

204-879-3

EC Name:

Ursodeoxycholic acid

Cas Number:

128-13-2

IUPAC Name:

3,7-dihydroxycholan-24-oic acid

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Results and discussion

Partition coefficient

Type:

log Pow

Partition coefficient:

3.38

Temp.:

20 °C

pH:

6

Applicant's summary and conclusion

Conclusions:

The experimental logPow of ursodeoxycholic acid at 20° C is 3.38.

Executive summary:

According to the OECD guideline 107 method, the expermental logPow of ursodeoxycholic acid at 20° C is 3.38.