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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study report which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report Date:
1978

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute toxicity upon intraperitoneal injection with 14-day observation period.
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Naphthalimid fest (solid)
- Physical state: solid
- Analytical purity: ca 99.5%

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 0.5% CMC in water
Details on exposure:
14-day observation
Doses:
2150, 3160 and 4600 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 4 600 mg/kg bw
Based on:
test mat.
Mortality:
At 4600 mg/kg bw, one male and one female animal died one day after exposure. During the second week after exposure, another two males died.
At the mid dose group, one male and one female animal died one day after exposure.
At the low dose group, one male died one day after exposure.
Clinical signs:
yes (bad general state and loss of body weight (partly until the second week after exposure); additionally unspecific symptoms like dyspnea, apathy, staggering, spastic gait
Body weight:
affected (in part strong body weight decrease after test substance administration)
Gross pathology:
Surviving animals showed no adverse findings upon necropsy.

Applicant's summary and conclusion