Naphthalene-1,8-dicarboximide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

disregarded due to major methodological deficiencies

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Unsuitable test system (inhalation hazard test with a solid)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

adopted 1981, Annex

Deviations:

yes

Remarks:

(determination of the test atmosphere by reweighing of a test substance column)

Principles of method if other than guideline:

7 h full body exposure to an atmosphere generated by blowing air through a layer of the test substance.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Naphthalene-1,8-dicarboximide

EC Number:

201-379-7

EC Name:

Naphthalene-1,8-dicarboximide

Cas Number:

81-83-4

Molecular formula:

C12H7NO2

IUPAC Name:

3-azatricyclo[7.3.1.0⁵,¹³]trideca-1(13),5,7,9,11-pentaene-2,4-dione

Details on test material:

- Name of test material (as cited in study report): Naphthalimid fest (solid)
- Physical state: solid
- Analytical purity: < 99.5%

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Mean weight at study initiation: males 219 g, females 178 g

ENVIRONMENTAL CONDITIONS
not reported

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

Rats were exposed for 7 h to a dust atmosphere in two trials with 6 animals per trial.
Dust was generated by bubbling 200 L/h dry air (no CO2) through a solid substance column of about 5 cm above a fritted glass disc in a glass cylinder at room temperature. The mean nominal concentration was stated in the raw data to be 0.13 mg/L, calculated on the basis of weight reduction of the substance column during the exposure period.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

nominal 0.13 mg/L

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weighing was done on d0 and d14. Detailed clinical observations were performed several times at the day of exposure and daily with the exception of weekends and holidays afterwards.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: IHT

Exp. duration:

7 h

Remarks on result:

other: No mortality observed after dust exposure for 7 hours.

Mortality:

No mortality observed.

Clinical signs:

other: not observed

Body weight:

normal body weight gain

Gross pathology:

Nothing abnormal found.

Any other information on results incl. tables

A weak dust formation was observed.