Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Rapporteur for the EU risk assessment of (3-chloro-2-hydroxypropyl)trimethylammonium chloride is the National Product Control Agency for Welfare and Health, Finland. The report is the result of in-depth work performed by experts in one Member State, working with counterparts in other Member States, Industry and public interest groups. The information reported is considered reliable.

Data source

Reference
Reference Type:
other: Published secondary source
Title:
Unnamed
Year:
2008
Report Date:
2008

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Details of the guideline followed not given
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Concentrations:
12.05 mg/L (3-chloro-2-hydroxypropyl)trimethylammonium chloride
No. of animals per sex per dose:
4
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: No deaths or changes in appearance, demeanour or food consumption
Effect level:
12.05 other: mg/L
Based on:
test mat.
Exp. duration:
7 h

Applicant's summary and conclusion

Conclusions:
A 7 hour inhalation exposure at a nominal concentration of 12.05 mg/L (3-chloro-2-hydroxypropyl)trimethylammonium chloride caused no deaths or changes in appearance, demeanour or food consumption in 4 rats.