Registration Dossier

Administrative data

Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2002
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Rapporteur for the EU risk assessment of (3-chloro-2-hydroxypropyl)trimethylammonium chloride is the National Product Control Agency for Welfare and Health, Finland. The report is the result of in-depth work performed by experts in one Member State, working with counterparts in other Member States, Industry and public interest groups. The information reported is considered reliable.

Data source

Reference
Reference Type:
other: Published secondary source
Title:
Unnamed
Year:
2008
Report Date:
2008

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
yes

Test organisms

Test organisms (species):
other: Activated sludge from sewage treatment plant

Study design

Test type:
not specified
Water media type:
not specified
Total exposure duration:
3 h

Test conditions

Reference substance (positive control):
not specified

Results and discussion

Effect concentrations
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
> 2 000 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
not specified

Applicant's summary and conclusion

Conclusions:
(3-Chloro-2-hydroxypropyl)trimethylammonium chloride is only slightly toxic to micro-organisms. In an activated sludge respiration inhibition test (OECD 209) no EC50 value could be found with the highest test concentration of 2000 mg/L.
Executive summary:

(3-Chloro-2-hydroxypropyl)trimethylammonium chloride is only slightly toxic to micro-organisms. In an activated sludge respiration inhibition test (OECD 209) no EC50 value could be found with the highest test concentration of 2000 mg/L.