Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1988
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Rapporteur for the EU risk assessment of (3-chloro-2-hydroxypropyl)trimethylammonium chloride is the National Product Control Agency for Welfare and Health, Finland. The report is the result of in-depth work performed by experts in one Member State, working with counterparts in other Member States, Industry and public interest groups. The information reported is considered reliable.

Data source

Reference
Reference Type:
other: Published secondary source
Title:
Unnamed
Year:
2008
Report Date:
2008

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:
semi-static
Water media type:
not specified
Total exposure duration:
96 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
4 128 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
not specified
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
2 094 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
not specified

Applicant's summary and conclusion

Conclusions:
(3-chloro-2-hydroxypropyl)trimethylammonium chloride is very slightly toxic to fish. In a short-term toxicity study the nominal LC50 value for fish is 4128 mg/L. The pH ranged from 6.5-8.0 and pH lower than 7.0 was observed with the highest test concentration (10000 mg/L nominal).
Executive summary:

(3-chloro-2-hydroxypropyl)trimethylammonium chloride is very slightly toxic to fish. In a short-term toxicity study the nominal LC50 value for fish is 4128 mg/L. The pH ranged from 6.5-8.0 and pH lower than 7.0 was observed with the highest test concentration (10000 mg/L nominal).