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EC number: 307-546-1 | CAS number: 97660-35-0
The goal of study is to assess the developmental toxicity and embryotoxic/teratogenic potential of high doses of target compound - AI(OH)3orally administered to rats during the period of active organogenesis.
No significant general/maternal toxicity was observed in any Al treated groups that were orally exposed to Al hydroxide at doses 66.5, 133 and 266 mg Al/kg bw/day.
The results have contributed to the weight of evidence on the lack of pre-natal developmental toxicity of Al hydroxide administered orally to rats at high doses (66.6; 133 and 266 mg Al/kg bw/day). Toxicokinetic studies support the reported negative developmental outcomes.
Well designed and conducted study with many studied endpoints comparable to guideline OECD TG 414 with acceptable deviations.
However, particular test data/relevant information are absent (physiochemical properties, identification including CAS number, details on food and water quality (Al content in diet, water); details on test substance formulations (preparation, pH, stability and homogeneity of the preparation), details on reported negative teratogenic effects are not provided.
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