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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
other: in vitro
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02. Jul. 2010 - 05.Jul. 2010
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD Guideline Part 431 (In vitro Skin Corrosion: Human Skin Model Test"
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Calcium, carbonate hydroxy aluminum complexes
EC Number:
307-546-1
EC Name:
Calcium, carbonate hydroxy aluminum complexes
Cas Number:
97660-35-0
Molecular formula:
Ca4Al2(OH)12CO3*5H20
IUPAC Name:
dialuminium(3+) tetracalcium dodecahydroxide carbonate

Test animals

Species:
other: EpiDerm tissue
Strain:
other: Epi-200-Kit

Test system

Type of coverage:
occlusive
Preparation of test site:
other: not applicable
Vehicle:
unchanged (no vehicle)
Controls:
other: EpiDerm tissues with H2O demin. as negative control; EpiDerm tissues with potassium hydroxid solution as posive control
Duration of treatment / exposure:
The human skin model EpiDerm was treated with CAHC for three minutes and one hour, respectively.
Observation period:
Three minutes respectively one hour.
Number of animals:
Two EpiDerm tissues were jused for the "three minute" experiment and two were jused for the "one hour" experiment.
Two EpiDerm tissues were jused as negative control, two tissues as positive control.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: Formazan Production
Basis:
mean
Time point:
other: 3 minutes
Score:
ca. 100
Reversibility:
no data
Irritation parameter:
other: Formazan Production
Basis:
mean
Time point:
other: 1 hour
Score:
ca. 98
Reversibility:
no data

Applicant's summary and conclusion

Interpretation of results:
other: not corrosive
Remarks:
Criteria used for interpretation of results: OECD GHS

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