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EC number: 307-546-1 | CAS number: 97660-35-0
In a subacute toxicity study according to OECD Guideline No. 407, Mai 12, 1981 and EEC Directive 84/449/EEC, Part B.7, September 1984, RV 777 (90 % a.i.) was administered to groups of 5 Wistar rats per dose and sex by gavage at dose levels of 0, 50, 200, and 1000 mg/kg bw/day.
In this study up to and including the highest dose tested (1000 mg/kg bw/day), no mortality occured and there were no changes in clinical appearance, body weights, food consumption, ophthalmoscopic examination, clinical laboratory investigations, macroscopic examinations, organ weights and microscopic examination that were considered to be an effect of treatment.
The NOAEL is 1000 mg/kg bw/day.
This subacute oral toxicity study in the rat is acceptable and satisfies the guideline requirements.
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