Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Study duration:
subacute
Species:
rat

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEC
2.5 mg/m³
Study duration:
chronic

Mode of Action Analysis / Human Relevance Framework

Additional information

Neither Ca(OH)2 nor Al(OH)3 both are the main constituents of CAHC are known as sensitisingsubstances. Long term studies for Ca(OH)2 and Al(OH)3 doesn´t show any sensitising properties. See additional Read-Across-Study for Al(OH)3 and Lit: Recommendation from the Scientific Committee on Occupational Exposure Limits for Calcium oxide (CaO) and calcium hydroxide (Ca(OH)2) and Draft human and environmental risk assessment of calcium hydroxide prepared by the Washington State Department of Ecology, March 2005

Justification for classification or non-classification