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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well documented guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Version / remarks:
adopted may12th, 1981
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Diphenylethoxyphospine
IUPAC Name:
Diphenylethoxyphospine
Details on test material:
- Name of test material (as cited in study report): Diphenylethoxyphosphin
- Physical state: liquid
- Analytical purity: no data
- Expiration date of the lot/batch: October 1982

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Gaukler, Offenbach/Main
- Age at study initiation: no data
- Weight at study initiation: males: 3.23kg on average, female: 2.59kg
- Housing: single in steel cages (40 x 51cm)
- Diet (e.g. ad libitum): Ovator Solikanin 4mm, app. 130g per animal daily
- Water (e.g. ad libitum): app. 250ml per animal and day (VE water on weekdays, tap water on weekends)
- Acclimation period: app. 8 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-26°C
- Humidity (%): app. 30-70%
- Photoperiod (hrs dark / hrs light): 12h/12h

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): app. 0.5ml
Duration of treatment / exposure:
4h under occlusive conditions
Observation period:
8 days (30-60min, 24h, 48h, 72h, and 8 days after exposure)
Number of animals:
2males, 1 female
Details on study design:
TEST SITE
- Area of exposure: 2.5 x 2.5cm

REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, using Lutrol and Lutrol/water (1:1)
- Time after start of exposure: 4h

SCORING SYSTEM:
Erythema and edema are scored accoring to the following scale:
0: no effect
1: slight effect
2: well discernable effect
3: moderate to strong effect
4: strong to very strong effect
In addition, scaling will be noted.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24-72h
Score:
1.6
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: animals #1,2
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24-72h
Score:
1.3
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: animal #3
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24-72h
Score:
1.3
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: animal #1
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24-72h
Score:
>= 0.3 - <= 0.6
Max. score:
4
Reversibility:
fully reversible within: 48h
Remarks on result:
other: animals #2,3
Other effects:
no effects observed during gross pathology

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information
Conclusions:
A single occlusive application of 0.5ml to intact rabbit skin for 4h elicited mild skin irritation.