Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-951-8 | CAS number: 719-80-2
Endpoint summary
Administrative data
Description of key information
skin:
rabbit, 4h, occlusive (BASF 1982, according to OECD 404): slight irritant
eye:
rabbit: substance not washed out (BASF 1982, OECD 405): not irritant
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin
In an acute dermal irritation/corrosion study according to OECD 404, 0.5 ml of the test substance were topically applied to the intact skin of 3 White Vienna rabbits for 4 hours under occlusive conditions (BASF 1982). The average score (24 to 72 hours) for irritation was 1.6 (2 rabbits and 1.3 (1 rabbit) for erythema and 1.3, 0.6, 0.3 for edema, thus the test substance was only slightly irritating in this assay. All skin reactions were reversible within 8 days at the latest.
Eye
3 white Vienna rabbits were subjected to a single ocular application of 0.1ml of the test substance in a study according to OECD 405 (BASF AG 1982) . The substance was not washed out and effects on the eyes were scored according to Draize. No effects on the iris, the cornea and no chemosis were oberserved in all animals after 24, 48, and 72h (score = 0). Conjunctival redness was observed after 24 and 48h, but not anymore after 72h. The mean score (24h-72h) was 0.6 for 2 rabbits and 1 for the third animal.
Justification for classification or non-classification
The available data on ethyl diphenylphosphinite indicate only a slight irritating potential to the skin and almost no irritating potential to the eye. The scores obtained in the in vivo tests do not justify classification according to 67/548/EEC or CLP/EU-GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
