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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP compliant guideline study, available as unpublished report, no restrictions, fully adequate for assessment.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
< 0.05 mg/L
Temp.:
19.9 °C
pH:
5.9
Conclusions:
The water solubility of the test substance was <0.05 mg/L at 19.9 ± 0.5 °C and pH of 5.9.
Executive summary:

Although preliminary tests showed the water solubility to be ≤ 10-2g/L, the column elution method was not applicable (undissolved test substance droplets in the eluates), so the flask method was used to determine the water solubility of the test substance. The water solubility of the test substance was <0.05 mg/L at 19.9±0.5°C and pH of 5.9.

Description of key information

Although preliminary tests showed the water solubility to be ≤ 10-2g/L, the column elution method was not applicable (undissolved test substance droplets in the eluates), so the flask method was used to determine the water solubility of the test substance. The water solubility of the test substance was <0.05 mg/L at 19.9 ± 0.5°C and pH of 5.9.

Key value for chemical safety assessment

Water solubility:
0.05 mg/L
at the temperature of:
19.9 °C

Additional information

Data from a GLP-compliant guideline study, fully adequate for assessment.