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EC number: 700-684-7 | CAS number: 80793-17-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro gene mutation test in bacteria
The mutagenic activity of AC-6000 was examined in the reverse mutation test by using bacterial strains Salmonella typhimurium TA100, TA1535, TA98 and 1537 and Escherichia coli WP2uvrA (Hita Laboratory, 2006). The GLP-compliant study was performed comparable to OECD guideline 471. The reverse mutation test was composed of a dose range finding and a main test. The pre-incubation method was used for all bacterial strains in both the presence and the absence of metabolic activation using the following concentrations: 4.88, 19.5, 78.1, 313, 1250 and 5000 µg/plate (dose range finding test) and 313, 625, 1250, 2500 and 5000 µg/plate (main test). In both the dose range finding test and the main test, the number of revertant colonies in the substance treatment groups in all test strains with and without S-9 mix was less than twice that in the solvent control. Bacterial growth inhibition and precipitation of the substance were not observed at any doses in the groups of treatment in all test strains with and without S-9 mix. Therefore it is concluded that the mutagenic activity of AC-6000 is considered negative under the test conditions employed.
In vitro chromosome aberration test with mammalian cells
The ability of AC-6000 to induce chromosomal aberrations was investigated by using Chinese hamster lung fibroblasts (CHL/IU cells) in a study comparable to OECD guideline 473 (Hita Laboratory, 2007). Based on the results of cell growth inhibition test, the concentrations of the test substance in the chromosomal aberration test were set at 870, 1740 and 3480 µg/mL in short-term treatments (6 hours) without and with S-9 mix and in a 24 hours continuous treatment. In the observation, the frequencies of cells with structural aberrations and numerical aberrations were scored.
Cytotoxicity was not observed. Precipitation of the test substance was observed at all concentrations. The frequencies of cells with structural and numerical aberrations were below 5% at all tested concentrations of the test substance in all treatment methods. It was concluded that AC-6000 did not induce chromosomal aberrations under the present test conditions.
Short description of key information:
The substance was negative both in an Ames test and in an in vitro
chromosomal aberration test.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the results of the in vitro tests, the substance does not need to be classified according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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