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Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Unpublished study report cited in a peer-reviewed publication
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified
Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
Weight at study initiation: ca. 2300 g
Type of coverage:
occlusive
Preparation of test site:
other: clipped intact or scarified skin
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
500 uL
Duration of treatment / exposure:
24 h
Observation period:
up to 72 h
Number of animals:
6 m
Details on study design:
not further specified
Irritation parameter:
overall irritation score
Remarks on result:
other: no details reported
Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The treatment gave no indications for skin irritation
Executive summary:

Diethyl carbonate was tested in rabbits in a study equivalent or similar to OECD Guideline 404. The treatment gave no indications for skin irritation.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Unpublished study report cited in a peer-reviewed publication
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
not specified
Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
Weight at study initiation: ca. 2300 g
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
100 uL
Duration of treatment / exposure:
not further specified
Observation period (in vivo):
up to 8 days
Number of animals or in vitro replicates:
6 m
Details on study design:
TOOL USED TO ASSESS SCORE: ophthalmoscope
Irritation parameter:
overall irritation score
Remarks on result:
other: no details reported
Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The treatment gave no indications for eye irritating properties
Executive summary:

Diethyl carbonate was tested in rabbits in a study equivalent or similar to OECD Guideline 405. The treatment gave no indications for eye irritation.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Diethyl carbonate was tested in rabbits in a study equivalent or similar to OECD Guideline 404. The treatment gave no indications for skin irritation.

Diethyl carbonate was tested in rabbits in a study equivalent or similar to OECD Guideline 405. The treatment gave no indications for eye irritation.

Justification for classification or non-classification

As diethyl carbonate showed no skin irritation and eye irritation, no classification according to EU and GHS criteria is required.