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Short-term toxicity to aquatic invertebrates

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Description of key information

The performance of a study on the short-term toxicity to aquatic invertebrates is not justified.

Key value for chemical safety assessment

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The calculation of the acute toxicity of diethyl carbonate to fresh and marine water invertebrates yielded 48 h LC50 values ranging from 102.6 to 220.1 mg/L for daphnids and a 96 h LC50=98.3 mg/L for mysid shrimp using ECOSAR v1.00.

The acute toxicity of the structurally related carbonate ester dimethyl carbonate to Daphnia magna was investigated in a study conducted according to EU Method C.2 (Acute Toxicity for Daphnia; 1992). In this static limit test, 20 daphnids were exposed to a nominal concentration of 100 mg DMC/L for 48 h. The concentrations of dimethyl carbonate in the test media were assessed by chemical analyses (GC/FID). Dimethyl carbonate proved to be not toxic to exposed daphnia up to the highest test substance concentration applied and so the 48 h EC50 was set to >100 mg/L and >74.16 mg/L based on the nominal and geometric mean measured concentrations, respectively.

For adverse effects to daphnia magna after exposure to the structurally related carbonate esters dimethyl carbonate (DMC) and ethylmethyl carbonate (EMC), the QSAR Toolbox predicts EC50 values for immobilisation of > 100 mg/l for each of the substances, indicating a very low toxicity potential.