Registration Dossier
Registration Dossier
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EC number: 203-311-1 | CAS number: 105-58-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Unpublished study report cited in a peer-reviewed publication
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Bericht ueber die Pruefung von Diaethylcarbonat auf Schleimhautreizwirkung (unpublished report)
- Author:
- Bayer AG
- Year:
- 1 981
- Bibliographic source:
- BG Chemie (1994) Toxicological Evaluations 7. Potential Health Hazards of Existing Chemicals. Springer Verlag
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diethyl carbonate
- EC Number:
- 203-311-1
- EC Name:
- Diethyl carbonate
- Cas Number:
- 105-58-8
- Molecular formula:
- C5H10O3
- IUPAC Name:
- diethyl carbonate
- Test material form:
- other: liquid
- Details on test material:
- not further specified
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Weight at study initiation: ca. 2300 g
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 100 uL
- Duration of treatment / exposure:
- not further specified
- Observation period (in vivo):
- up to 8 days
- Number of animals or in vitro replicates:
- 6 m
- Details on study design:
- TOOL USED TO ASSESS SCORE: ophthalmoscope
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks on result:
- other: no details reported
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The treatment gave no indications for eye irritating properties
- Executive summary:
Diethyl carbonate was tested in rabbits in a study equivalent or similar to OECD Guideline 405. The treatment gave no indications for eye irritation.
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