Registration Dossier
Registration Dossier
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EC number: 203-311-1 | CAS number: 105-58-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1966
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Untersuchungen zur Toxikologie von Diaethylcarbonat
- Author:
- Bornmann G & Loeser A
- Year:
- 1 966
- Bibliographic source:
- Arch Toxicol 22, 98-114
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- see below
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diethyl carbonate
- EC Number:
- 203-311-1
- EC Name:
- Diethyl carbonate
- Cas Number:
- 105-58-8
- Molecular formula:
- C5H10O3
- IUPAC Name:
- diethyl carbonate
- Test material form:
- other: liquid
- Details on test material:
- Purity: > 99.5%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Weight at study initiation: 200-340 g
Housing: individually
Diet: ad libitum
Water: ad libitum
ENVIRONMENTAL CONDITIONS
Temperature (°C): 26-28
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Concentration in vehicle: 60 % (w/v)
- Doses:
- 22-37 mL/kg
- No. of animals per sex per dose:
- 5 m / 5 f
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: up to 10 days
Necropsy of survivors performed: no data
Other examinations performed: clinical signs - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 15 000 mg/kg bw
- Mortality:
- yes, but not further specified
- Clinical signs:
- other: predominant sign of toxicity was narcosis
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- In male and female Wistar rats a LD50 value of > 15000 mg/kg bw was reported. The predominant sign of toxicity was narcosis.
- Executive summary:
In male and female Wistar rats a LD50 value of > 15000 mg/kg bw was reported. The predominant sign of toxicity was narcosis.
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