Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study summary report
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
ROBUST SUMMARY OF INFORMATION ON LUBRICATING OIL BASESTOCKS
Author:
American Petroleum Institute
Year:
2003
Bibliographic source:
ROBUST SUMMARY OF INFORMATION ON LUBRICATING OIL BASESTOCKS pag 28

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
other: The test procedure was consistent with that given in OECD Guideline 402 (1987)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
1 day
Doses:
2 g /kg
No. of animals per sex per dose:
4
Control animals:
not required

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
not specified

Any other information on results incl. tables

There were no mortalities during the study. With the exception of skin irritation, there were no clinical signs of toxicity except that on day 4 soft stool was observed in 1 male and 3 female animals. Dermal irritation ranged from slight to severe for erythema and edema, from slight to marked for fissuring and slight to moderate for atonia and desquamation. Slight coriaceousness was also observed. Body weight losses were recorded for 2 male and 3 female animals at day 7. One male was less than starting weight on both day 7 and day 14.

Applicant's summary and conclusion