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EC number: 297-474-6 | CAS number: 93572-43-1 A complex combination of hydrocarbons obtained by refining of crude oil. It consists predominantly of aromatics, naphthenics and paraffinics and produces a finished oil with a viscosity of 120 SUS at 100°F (23cSt at 40°C).
Actual exposure concentrations and mortalities were as follows:
Particle size measurements confirmed that mass median aerodynamic diameter and geometric standard deviation values were in the ranges 1.7 to 2.5 mµ and 1.5 to 1.61 respectively. These measurements confirm that the particles were within the respirable range. The LC50 for combined sexes was estimated to be 2.18 with 95% confidence limits of 1.80 to 2.55 mg/l. Body weight differences did not show a consistent dose related pattern. At the highest concentration, the animals were obscured by a dense aerosol and observations could not be made during the exposure period. In other groups, there was a decreased activity, wet inguinal area, eyes partially closed, wet coat, loose stool and oily coat during exposure. During the first week post-exposure, similar signs were observed as well as signs of poor condition, respiratory distress and some deaths occurred. During test week 2, most survivors were considered to be of normal appearance. The signs that were observed occurred in a dose related manner.
At histology, affected animals exhibited diffuse pulmonary congestion and perivascular edema that were mostly moderate or marked in degree. Less consistently spotty alveolar edema was also seen. There was widespread damage to alveolar walls resulting in fibronecrotic debris resembling hyaline membranes in more marked cases and extravasation of RBCs and PMNs. Necrosis and inflammation were seen in the walls of small blood vessels and there was spotty epithelial necrosis in small bronchioles, but the most severe damage seemed to be centroacinar. The larger airways were relatively unaffected. None of the surviving animals exhibited the above acute changes. However, most of the surviving animals exposed to 2.5 or 1.0 mg/l and above exhibited chronic inflammatory changes that were not seen in the controls and only occasionally in animals exposed at the 1.5 mg/l level, and then to a lesser degree of severity. Other findings were considered sporadic or unrelated to exposure to the test material.
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