Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The partition coefficient was obtained by the method described on the EU Method A.8.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
1-Amino-1-cyclopropanecarbonitrile hydrochloride
EC Number:
629-718-8
Cas Number:
127946-77-4
Molecular formula:
C4H7N2Cl
IUPAC Name:
1-Amino-1-cyclopropanecarbonitrile hydrochloride
Constituent 2
Reference substance name:
1-aminocyclopropane-1-carbonitrile hydrochloride
IUPAC Name:
1-aminocyclopropane-1-carbonitrile hydrochloride

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
ca. 2.72
Temp.:
25 °C
pH:
ca. 5.5

Applicant's summary and conclusion

Conclusions:
Partition coefficient : log Pow =2.72+-0.50