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EC number: 700-071-4 | CAS number: 932742-30-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
SIKA Hardener LI was tested in an acute oral toxicity study according to EU method B.1tris and OECD guideline 423. No treatment related effects were observed up to dose levels of 2000 mg/kg bw. The LD50-value was greater 2000 mg/kg bw and the NOEL 2000 mg/kg bw. SIKA Hardener LI was tested in an acute dermal toxicity study according to EU method B.3 and OECD guideline 402. No treatment related effects were observed up to dose levels of 2000 mg/kg bw. The LD50-value was greater 2000 mg/kg bw and the NOEL 2000 mg/kg bw. Testing via the inhalation route was waived, according to REACH Regulation (EC) No 1907/2006, Annex VIII, 8.5.2.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- GLP and Guideline study
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- GLP and Guideline study
Additional information
Acute toxicity oral
The acute toxicity oral of SIKA Hardener LI was tested according to EU method B.1tris and OECD guideline 423 (limit test). Two groups of three female Wistar rats were treated with SIKA Hardener LI by a single oral (gavage) administration at a dose level of 2000 mg/kg bw using Polyethylene glycol as a vehicle. The concentration of Polyethylene Glycol in formulations was 200 mg/mL administered by a constant treatment volume of 10 mL/kg bw. No mortalities were recorded. No clinical signs were observed under the duration of the 14 days observation period. The body weight gain of the animals was considered to be normal with no indication of test item related effect. The macroscopic examination revealed some minor alterations as mottled pale areas in the liver, diffuse dark red discolouration of the lung, dark focus on the lung and collapsed lung. As these changes were considered to be agonal or incidental it was concluded that under the conditions of the present study, a single oral administration of the test item SIKA Hardener LI, at a dose level of 2000 mg/kg bw did not cause any treatment related adverse effects. Therefore the acute oral LD0 and LD50 values of SIKA Hardener LI were determined 2000 mg/kg bw and greater than 2000 mg/kg bw .
Acute toxicity dermal
SIKA Hardener LI was tested in an acute dermal toxicity study according to EU method B.3 and OECD guideline 402 (limit test). Five male and five female Wistar rats were treated with a single administration at a dose level of 2000 mg/kg bw in its original form for 24 h in a semi-occlusive manner. No mortalities occurred, neither in male nor in female rats during the 14 days observation period. Behaviour and general state of animals were considered to be normal. All pathological findings were considered incidental changes with no indication of test item related effects. Thus, under the conditions of this study, SIKA Hardener LI did not induce any test item related adverse effects. The acute dermal LD0 and LD50 -values of SIKA Hardener LI were considered to be 2000 mg/kg bw and greater than 2000 mg/kg bw, respectively.
Acute toxicity inhalation
Additional testing by inhalation route is not applicable as an acute oral toxicity study and an acute dermal toxicity study were performed. According to the REACH Regulation No. 1907/2006, Annex VIII, 8.5 only two acute dose toxicity studies are required, with test item administration via the most appropriate route.
Justification for selection of acute toxicity – oral endpoint
only one study available
Justification for selection of acute toxicity – dermal endpoint
only one study available
Justification for classification or non-classification
Based on results obtained in acute toxicity studies SIKA Hardener LI was not classified and labelled according to Directive 67/548/EEC (DSD) and Regulation (EC) No 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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