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EC number: 700-071-4
CAS number: 932742-30-8
The acute skin irritation study of
2,2-Dimethyl-3-lauroyloxy-propanal was performed in New Zealand White
rabbits. The irritation effect of the test item was evaluated according
to the Draize method (OECD No.: 404, 2002). The test item was
administered in a pure state, as a single dose of 0.5 mL, to the shaved
skin of all experimental rabbits. The untreated skin of each animal
served as control. After 4 hours any remaining test item was removed
with water at body temperature. The animals were examined at 1, 24, 48
and 72 hours after the patch removal. No irritation symptoms (erythema
and oedema) or other signs occurred after the patch removal and during
the 72-hour observation period, so the study was terminated at the 72nd
hour. During the study the behaviour and general state of animals were
normal. The animal’s individual mean scores (considering readings at 24,
48 and 72 hours after patch removal) for erythema and oedema were 0.00,
0.00, 0.00 and 0.00, 0.00, 0.00 respectively. Thus, the classification
of the test item 2,2-Dimethyl-3-lauroyloxy-propanal as a skin irritant
is not required.
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