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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

One key study has been identified as having assessed the repeat-dose oral toxicity of ethyl methyl carbonate. 

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
1 000 mg/kg bw/day
Study duration:

Additional information

Repeated dose oral:

The repeated dose toxicity of ethyl methyl carbonate has been determined in a sub-acute oral gavage study in rats. In a 14-day range-finding oral gavage study conducted prior to a 28-day sub-acute study, rats (3 males and 3 females per treatment group) were treated with 0, 500 and 1000 mg/kg/day. No mortality or signs of toxicity were observed in any dose group, although a possible reduction in bodyweight may have occurred in week 2. Based on the findings of the range-finding study, the 28-day oral gavage study used doses of 15, 150 and 1000 mg/kg/day. The only treatment-related clinical finding in the main test was that females of the 1000 mg/kg treatment group displayed isolated cases of hypersalivation after dosing on day 5 and hunched posture from day 14 onwards. No treatment-related signs of toxicity were observed in males of any other dose group (nor in females of the 15 and 150 mg/kg dose group). Based on these findings the NOAEL for male rats is >=1000 mg/kg and the NOAEL for female rats is 1000 mg/kg.  

Justification for classification or non-classification

Based on the results of the repeat-dose (subacute) toxicity study via the oral route, ethyl methyl carbonate is:

- Not classified in accordance with the criteria given in Regulation 1272/2008 (EU CLP GHS).

- Not classified in accordance with the criteria given in Directive 67/548/EEC (DSD).