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EC number: 433-480-9 | CAS number: 623-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test using close chemical analogue. Study design and performance appear comparable to OECD guideline. Original source reference is not accessible but results are summarised in sufficient detail in secondary sources to allow proper assessment.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Developmental toxicity evaluation of dimethylcarbonate by inhalation in CD-1 mice
- Author:
- Bevan and Beyer
- Year:
- 1 995
- Bibliographic source:
- International Toxicologist 7(1) 74-P-2
- Reference Type:
- secondary source
- Title:
- Office of Environmental Hazard Assessment Final Revised Health Assessment For Dimethyl Carbonate
- Author:
- Californian Environmental Protection Agency
- Year:
- 2 010
- Bibliographic source:
- OEHHA Assessment, Appendix B (detailed summary of 1995 International Toxicologist paper)
- Reference Type:
- secondary source
- Title:
- Non-human toxicity excerpts: peer-reviewed summary of 1995 International Toxicologist paper
- Author:
- HSDB Database
- Year:
- 2 011
- Bibliographic source:
- US National Library of Medicine Toxicology Data Network
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Principles of method if other than guideline:
- Mouse inhalation teratology study
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dimethyl carbonate
- EC Number:
- 210-478-4
- EC Name:
- Dimethyl carbonate
- Cas Number:
- 616-38-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- dimethyl carbonate
- Details on test material:
- Dimethyl carbonate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Details on test animals or test system and environmental conditions:
- Mated females
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- air
- Details on exposure:
- Exposure 6h/day for 10 days
- Analytical verification of doses or concentrations:
- not specified
- Details on mating procedure:
- Not specified
- Duration of treatment / exposure:
- 6h/day
- Frequency of treatment:
- Daily in days 6-15 of gestation (post-mating)
- Duration of test:
- Parental females terminated on day 18 of gestation
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0 ppm
Basis:
other: control group
- Remarks:
- Doses / Concentrations:
300 ppm
Basis:
other: presumed target concentration (low-dose)
- Remarks:
- Doses / Concentrations:
1000 ppm
Basis:
other: presumed target concentration (mid-dose)
- Remarks:
- Doses / Concentrations:
3000 ppm
Basis:
other: presumed target concentration (high-dose)
- No. of animals per sex per dose:
- 96 mated females/dose
- Control animals:
- yes
- Details on study design:
- Foetuses from first 30-32 pregnant females/group taken for foetal examinations
Examinations
- Maternal examinations:
- Bodyweights recorded on days 0, 15 and 18 post-mating; food intakes recorded
- Ovaries and uterine content:
- Post-implantation losses determined from counts of resorptions
- Fetal examinations:
- Weights and sexes noted, inspected for abnormalities (external appearance, visceral and skeletal examination)
- Statistics:
- Statistical significance of any differences between test and control groups was determined
- Indices:
- Maternal toxicity assessed by bodyweight gain and food intake. Developmental effects assessed by foetal bodyweights and incidence of malformations
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:yes
Details on maternal toxic effects:
At 3000 ppm only, bodyweight gains days 0-15 and 0-18 both significantly reduced compared to controls (p<0.01): over days 0-18, bodyweight gain was 27% lower than controls (based on group mean values).
Food intakes significantly reduced at 1000 and 3000 ppm
Effect levels (maternal animals)
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 1 000 ppm
- Basis for effect level:
- other: maternal toxicity
- Dose descriptor:
- NOAEL
- Effect level:
- 1 000 ppm
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes
Details on embryotoxic / teratogenic effects:
Embryo/foetal toxicity at 3000 ppm: post-implantation losses, altered sex ratio with less surviving males. Foetal bodyweights significantly reduced (both sexes p<0.01) and more foetuses <1g weight.
Teratogenicity at 3000 ppm: cases of fused vertebral arches and skullbone malformations, plus skeletal (sternal and rib bone) variations seen at 3000 ppm only.
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Externally visible foetal abnormalities at 3000 ppm (significantly different from controls):
140/277 foetuses in 26/29 litters with cleft palate (p<0.01)
24/277 foetuses in 5/29 litters with small ears (p<0.05)
13/277 foetuses in 5/29 litters with abnormal ear position (p<0.05)
5/277 foetuses in 3/29 litters with unperforated anus (p<0.05)
4/277 foetuses in 2/29 litters with absent or undersized digit(s) (p<0.05).
Skeletal abnormalities at 3000 ppm:
- multiple skullbone malformations
- fused vertebral arches.
Skeletal variation at 3000 ppm:
- sternal bones misshaped
- rib bone shape/size variation.
Applicant's summary and conclusion
- Conclusions:
- Based on the high exposure concentrations required to cause significant embryo or foetal toxicity and foetal abnormalities, and the close association with maternal toxicity (NOAELs being the same for maternal and developmental toxicity), it is concluded that dimethyl carbonate did not show selective developmental toxicity. It is reasonable to assume that ethyl methyl carbonate would show closely similar activity in this type of study.
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