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Description of key information

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
140 mg/kg bw/day
Study duration:

Justification for classification or non-classification

Additional information

The data suggested that the conclusion of the diethyl carbonate as a cancerogen is not sufficient, the reason please see below:

- No adverse effect related to the treatment was found in this study, although there were some findings in mortality, rate of body-weight gain, histopathology, hematology and the weight of organ, but these findings were not related to the treatment. And the author also set the no-untoward-effect level was 1000 ppm (approx. 140 mg/kg/day) (Brown et al. (1978) ).

- Both the control group and the treated group had skin or lung tumours, it means the croton used in control group and the treatment may cause the tumour, so the conclusion of carcinogenicity is not sufficient. ( Berenblum, l. et al. (1959)).

- In this study, the tumour only was found in the treated group, so the cancerogenic effect couldn't be excluded completely. (Salaman, M.H and Roe, F.J.C.(1956)).

As diethyl carbonate is an analogue of methyl ethyl carbonate, the carcinogenicity of diethyl carbonate is not sufficient, so we could conclude the carcinogenicity of methyl ethyl carbonate is also insufficient.