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Ecotoxicological information

Long-term toxicity to fish

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Reference
Endpoint:
long-term toxicity to fish, other
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
Estimation of 28 days NOEC value for long term toxicity to fish using the ECOSAR version 1.11.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: Fish
Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
28 d
Reference substance (positive control):
no
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
1.09 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of effects observed in a flow through freshwater system on test organism, the NOEC value for the substance was estimated to be 1.09 mg/l for fish for 28 days of exposure duration.
Executive summary:

Based on the prediction done using ECOSAR version 1.11, the long term toxicity on fish was predicted for test chemical. On the basis of effects observed in a flow through freshwater system on test organism, the NOEC value for the substance was estimated to be 1.09 mg/l for fish for 28 days of exposure duration. Thus, it can be concluded that the test chemical can be considered as non-toxic to fish at environmentally relevant concentrations.

Description of key information

Based on the prediction done using ECOSAR version 1.11, the long term toxicity on fish was predicted for test chemical (2017). On the basis of effects observed in a flow through freshwater system on test organism, the NOEC value for the substance was estimated to be 1.09 mg/l for fish for 28 days of exposure duration. Thus, it can be concluded that the test chemical can be considered as non-toxic to fish at environmentally relevant concentrations.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
1.09 mg/L

Additional information

Based on the prediction done using ECOSAR version 1.11, the long term toxicity on fish was predicted for test chemical (2017). On the basis of effects observed in a flow through freshwater system on test organism, the NOEC value for the substance was estimated to be 1.09 mg/l for fish for 28 days of exposure duration. Thus, it can be concluded that the test chemical can be considered as non-toxic to fish at environmentally relevant concentrations.