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Long-term toxicity to aquatic invertebrates

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Description of key information

The study outlines the adverse effects of test chemical on reproduction of Daphnia magna, the test was conducted following the OECD guidelines 211 (Experimental study report, 2018). A semi static regime was followed in which the test chemical was renewed at every alternate day till 21 days of study. Nominal concentrations were used i.e., from of 0.625 mg/L, 1.25 mg/L, 2.5 mg/L, 5 mg/L and 10 mg/L, and reproduction effect was studied for 21 days based on the number of off springs produced. All the validity criteria were fulfilled per OECD guidelines. The median effective concentration (EC50) and effective concentration at 10% inhibition was determined as 5.89±1.76 and 1.20± 0.6 mg/L, respectively. Thus, it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
1.2 mg/L

Additional information

The study outlines the adverse effects of test chemical on reproduction of Daphnia magna, the test was conducted following the OECD guidelines 211 (Experimental study report, 2018). A semi static regime was followed in which the test chemical was renewed at every alternate day till 21 days of study. Nominal concentrations were used i.e., from of 0.625 mg/L, 1.25 mg/L, 2.5 mg/L, 5 mg/L and 10 mg/L, and reproduction effect was studied for 21 days based on the number of off springs produced. All the validity criteria were fulfilled per OECD guidelines. The median effective concentration (EC50) and effective concentration at 10% inhibition was determined as 5.89±1.76 and 1.20± 0.6 mg/L, respectively. Thus, it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations.