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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard OECD test guidelines
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Principles of method if other than guideline:
The water solubility determination of test chemical was done as per the OECD Guideline 105 (Water Solubility) and by spectrophotometric analytical method as per OECD 101.
GLP compliance:
no
Type of method:
other: spectrophotometric analytical method
Key result
Water solubility:
49.23 mg/L
Conc. based on:
test mat.
Temp.:
25 °C
pH:
3.99
Remarks on result:
other: Other details not known

ANALYTICAL DETERMINATION

PRELIMINARY TEST AT 24 h

Concentration obtained

(mg/L)

Average

Absorbance

Average

Total Dilution

factor(if any)

Water

Solubility

Value by

Standard

Curve (mg/L)

Average

R1

4.82

4.82

1.37

1.37

20

96.4

96.4 mg/l

R2

4.82

 

1.37

 

20

96.4

 

 

CONFIRMATORY TEST AT 24, 48 AND 72 h

Sample

stirring

(hours)

Concentration obtained

Average

Absorbance

Average

Dilution

factor

Water

Solubility

Value by

Standard

Curve (mg/L)

Average

24 h

R1

2.47

2.48

0.70

0.70

20

49.4

49.6

mg/L

24 h

R2

2.49

 

0.71

 

 

49.8

 

48 h

R1

1.60

2.59

0.45

0.73

20

32

51.8

mg/L

48 h

R2

3.58

 

1.02

 

 

71.6

 

72 h

R1

2.20

2.31

0.62

0.65

20

44

46.3

mg/L

72 h

R2

2.43

 

0.69

 

 

48.6

 

 

Calculations:

The water solubility for 24 h, 48 h and 72 h was calculated as follows: Mean water solubility value for 24 h + 48 h + 72 h run sample.

= (49.6+51.8+46.3)/3

= 49.23 mg/L

pH

pH

 

Preliminary test

Confirmatory test

 

24 h

24 h

48 h

72 h

R1

3.47

4.06

4.08

3.84

R2

3.62

4.03

4.04

3.94

Conclusions:
The water solubility determination of test chemical was done by spectrophotometric method. The water solubility was determined to be 49.23 mg/L.
Executive summary:

The water solubility determination of test chemical was done as per the OECD Guideline 105 (Water Solubility) and by spectrophotometric analytical method as per OECD 101. The solubility of test chemical in water was determined to be 49.23 mg/l. On the basis of this value, test chemical was considered to be slightly soluble in water.

Description of key information

Based on the available data from study report,the water solubility determination of test chemical was done as per the OECD Guideline 105 (Water Solubility) and by spectrophotometric analytical method as per OECD 101. The solubility of test chemical in water was determined to be 49.23 mg/l. On the basis of this value, test chemical was considered to be slightly soluble in water.

Key value for chemical safety assessment

Water solubility:
49.23 mg/L
at the temperature of:
25 °C

Additional information

Based on the available data from study report,the water solubility determination of test chemical was done as per the OECD Guideline 105 (Water Solubility) and by spectrophotometric analytical method as per OECD 101. The solubility of test chemical in water was determined to be 49.23 mg/l. On the basis of this value, test chemical was considered to be slightly soluble in water.