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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on three hydrolysis studies as-
2., 3. and 4.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Temp.:
25 °C
Remarks:
2. Study was performed at pH 4, 7 and 9, respectively.
Duration:
5 d
Temp.:
50 °C
Remarks:
3. Study was performed at pH 4, 7 and 9, respectively.
Temp.:
25 °C
Remarks:
4. Study was performed at pH 7 and 8.
Transformation products:
not specified
pH:
4
Temp.:
25 °C
Remarks on result:
other: 2. Test chemical was reported to be stable in water.
pH:
7
Temp.:
25 °C
DT50:
65.9 d
Remarks on result:
other: 2. Other details not known
pH:
9
Temp.:
25 °C
DT50:
1.04 d
Remarks on result:
other: 2. Other details not known
Temp.:
50 °C
DT50:
> 5 d
Remarks on result:
other: 3. Study was performed at pH 4, 7 and 9, respectively. Hydrolysis of test chemical did not reach > 10% at any pH system.
pH:
7
Temp.:
25 °C
DT50:
61 d
Type:
second order
Remarks on result:
other: 4. Hydrolysis rate constant of test chemical was determined to be 1.3 L/mol-sec
pH:
8
Temp.:
25 °C
DT50:
6 d
Type:
second order
Remarks on result:
other: 4. Hydrolysis rate constant of test chemical was determined to be 1.3 L/mol-sec
Details on results:
2. Test chemical was reported to be hydrolytically stable at pH 4, 7 & 9 and at 25°C, respectively.
3. Test chemical was reported to be hydrolytically stable at pH 4, 7 & 9 and at 50°C, respectively.
4. Details not known
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 61 to 65.9 days at pH 7.0 and 25°C temperature, respectively. Thus, based on this half-life value, test chemical can be considered to be hydrolytically stable.
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

The hydrolysis half-life of the test chemical was determined at different pH andat 25°C temperature.The study was performed following the the OECD Guideline 111 (Hydrolysis as a Function of pH).The half-lives of test chemical was determined to be 65.9 and 1.04 days at pH 7 and 9 & at a temperature of 25°C and was reported to be stable at pH 4.0. Based on this, it is concluded that the chemical was hydrolytically stable.

In a supporting weight of evidence study, the hydrolysis half-life of the test chemical was determined. The study was performed in accordance with the OECD Guideline 111 (Hydrolysis as a Function of pH). Preliminary test was carried out for 5 daysat different pH and at temperature of 50°C. Hydrolysis of test chemical did not reach > 10% at any pH system. Thus, the half-lives of test chemical was determined to be > 5 days at pH 4, 7 and 9 & at 50°C. Based on this, it is concluded that the chemical was hydrolytically stable.

For the test chemical, the half-life and base catalyzed second order hydrolysis rate constant was determined of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 1.3L/mol-sec with a corresponding half-lives of 61 and 6 days at pH 7 & 8 and 25°C temperature, respectively. On the basis of the half-life value at pH 7.0 (i.e, 61 days), it is concluded that the test chemical was stable in water.

On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 61 to 65.9 days at pH 7.0 and 25°C temperature, respectively. Thus, based on this half-life value, test chemical can be considered to be hydrolytically stable.

Description of key information

On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 61 to 65.9 days at pH 7.0 and 25°C temperature, respectively. Thus, based on this half-life value, test chemical can be considered to be hydrolytically stable.

Key value for chemical safety assessment

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

 

The hydrolysis half-life of the test chemical was determined at different pH andat 25°C temperature.The study was performed following the the OECD Guideline 111 (Hydrolysis as a Function of pH).The half-lives of test chemical was determined to be 65.9 and 1.04 days at pH 7 and 9 & at a temperature of 25°C and was reported to be stable at pH 4.0. Based on this, it is concluded that the chemical was hydrolytically stable.

 

In a supporting weight of evidence study, the hydrolysis half-life of the test chemical was determined. The study was performed in accordance with the OECD Guideline 111 (Hydrolysis as a Function of pH). Preliminary test was carried out for 5 daysat different pH and at temperature of 50°C. Hydrolysis of test chemical did not reach > 10% at any pH system. Thus, the half-lives of test chemical was determined to be > 5 days at pH 4, 7 and 9 & at 50°C. Based on this, it is concluded that the chemical was hydrolytically stable.

 

For the test chemical, the half-life and base catalyzed second order hydrolysis rate constant was determined of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 1.3L/mol-sec with a corresponding half-lives of 61 and 6 days at pH 7 & 8 and 25°C temperature, respectively. On the basis of the half-life value at pH 7.0 (i.e, 61 days), it is concluded that the test chemical was stable in water.

 

On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 61 to 65.9 days at pH 7.0 and 25°C temperature, respectively. Thus, based on this half-life value, test chemical can be considered to be hydrolytically stable.