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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2013-01-29 to 2013-02-18
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
Version / remarks:
(CIPAC MT 187)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: ISO 13320-1
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of distribution:
counted distribution
Percentile:
D50
Mean:
ca. 30.7 µm
Remarks on result:
other: the mass moment mean (De Brouckere Mean Diameter)(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)
Percentile:
D10
Mean:
5.1 µm
Remarks on result:
other: average value from five measurements
Percentile:
D50
Mean:
25.3 µm
Remarks on result:
other: average value from five measurements
Percentile:
D90
Mean:
61.2 µm
Remarks on result:
other: average value from five measurements

A histogram showing the particle size distribution of ASC plus is attached as a TIFF File (see section "Overall remarks, attachments" -file: Particle Size Distribution ASC plus)

Conclusions:
The average particle size of 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid is 30.7 µm. Only 6.3% (average of five measurements) of the
particles showed a size of < 2 µm representing the small respirable fraction.
Executive summary:

The particle size distribution analysis of 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid (ASC plus) was performed according to the OECD 110 guideline (laser diffraction method). The average particle size of ASC plus is 30.7 µm. Information regarding the percentile of the particle size distribution is as follows: D10 = 5.1 µm, D50 = 25.3 µm and D90 = 61.2 µm. Only 6.3% (average of five measurements) of the particles showed a size of < 2 µm representing the small respirable fraction.

Description of key information

The particle size distribution analysis of 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid (ASC plus) was performed according to the OECD 110 guideline. The particle size was determined using the laser diffraction method and the Coulter LS 230 as apparatus. The   average particle size of ASC plus is 30.7 µm. Information regarding the percentile of the particle size distribution is as follows: D10 = 5.1 µm, D50 = 25.3 µm and D90 = 61.2 µm. Only 6.3% (average of five measurements) of the particles showed a size of < 2 µm representing the small respirable fraction. A histogram showing the particle size distribution of ASC plus is attached.

Additional information