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EC number: 278-934-5 | CAS number: 78521-39-8
ASC plus was tested in a guinea pig maximisation test according to OECD 406 for its sensitising properties. In 2 pilot studies with one male and one female animal in each study the effects of an intradermal injection of 0.1 ml of a 5% formulation in water with Freund's complete adjuvans and the effect of a dermal application of 0.5 g of a formulation in vaseline were tested.
48 hours after the end of the application no effects were seen in comparison to the pure vehicle.
In the main study with 5 male and 5 female animals a first induction was started with the intradermal injection of 0.1 ml of a 5 % formulation in water with Freund's complete adjuvans.
The second induction was done 7 days later by an occlusive dermal application of 0.5 g of a formulation in vaseline.
14 days after the end of the 2nd induction the challenge was done by an occlusive dermal application of a 50 % formulation in vaseline for 24 hours. The effect was controlled 24 and 48 hours after the end of the application.
The animals of the treatment group recieved also applications of vehicle only at another part of the back. 3 male and 2 female guinea pigs of a control group recieved vehicle only.
With the treatment groups no effects were seen at any time point during the study.
After treatment with pure vaseline a light reddening of the skin was observed at the time point 24 hours after the end of the challenge.
The positive control was done by a seperate study in the time from 2000-07-11 to 2000 -08 -04.
According to the results of this study ASC plus is not sensitising.
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