Butan-2-one O,O',O''-(vinylsilylidyne)trioxime

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From October 20, 1981 to February 19, 1982

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

Bioaccumulation test in fish performed by MITI.

Qualifier:

according to guideline

Guideline:

other: Bioaccumulation test of a chemical substance in fish or shellfish

GLP compliance:

not specified

Vehicle:

not specified

Test organisms (species):

Cyprinus carpio

Route of exposure:

aqueous

Test type:

flow-through

Total exposure / uptake duration:

6 wk

Details on test conditions:

RANGE-FINDING/PRELIMINARY STUDY Test concentrations: 48hr TLm: 560ppm, Rice fish (Oryzias latipes).

Nominal and measured concentrations:

1st Concentration area 2ppm, 2nd Concentration area 0.2ppm.

Lipid content:

4.9 %

Remarks on result:

other: E G. Bligh and W. J. Dyer, Can. J. Biochem. Physiol., 37, 911 (1959)

Key result

Conc. / dose:

2 mg/L

Type:

BCF

Value:

>= 0.5 - <= 0.6 dimensionless

Key result

Conc. / dose:

0.2 mg/L

Type:

BCF

Value:

ca. 2.5 - <= 5.8 dimensionless

Validity criteria fulfilled:

not specified

Conclusions:

The test item butanone oxime was determined to have a low bioconcentration potential.

Executive summary:

A bioaccumulation test in fish was performed by MITI on test substance butanone oxime. A range finding study was performed on Rice fish (Oryzias latipes) were LC50 after 48 hours exposure was 560 ppm. In the main test, carp fish (Cyprinus carpio) were exposed to 2 (1st concentration area) and 0.2 ppm (2nd concentration area) test substance during 6 weeks in an aqueous flow-through system. The lipid content was 4.9%. The biocconcentration factor (BCF) for butonone oxime was determined to be (0.5)-(0.6) at a concentration of 2 ppm, and <2.5 -(5.8) at a concentration of 0.2 ppm. The test substance was determined to have a low bioconcentration potential.

Reference 2

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH
Butan-2-one O,O',O''-(vinylsilanetriyl)oxime undergoes rapid hydrolysis in aqueous to butanone oxime and the corresponding silanol. Silanetriol undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, both butan-2-one O,O',O''-(vinylsilanetriyl)oxime and butanone oxime have comparable values for the relevant molecular properties for bioaccumulation.
See attached the reporting format.

Reason / purpose for cross-reference:

read-across: supporting information

Key result

Conc. / dose:

2 mg/L

Type:

BCF

Value:

>= 0.5 - <= 0.6 dimensionless

Remarks on result:

other: (results from an analogue)

Key result

Conc. / dose:

0.2 mg/L

Type:

BCF

Value:

ca. 2.5 - <= 5.8 dimensionless

Remarks on result:

other: (results from an analogue)

Validity criteria fulfilled:

not applicable

Conclusions:

Based on read-across approach from experimental data on analogue butanone oxime, butan-2-one O,O',O''-(vinylsilanetriyl)oxime was determined to have a low bioconcentration potential.

Executive summary:

Based on published experimental data on analogue butanone oxime, where a bioaccumulation test in carp fish was performed by MITI during 6 weeks in an aqueous flow-through system and the biocconcentration factor was determined to be (0.5)-(0.6) at a concentration of 2 ppm, and <2.5 -(5.8) at a concentration of 0.2 ppm, the read-across was applied and butan-2-one O,O',O''-(vinylsilanetriyl)oxime was determined to have a low bioconcentration potential.

Reference 3

Endpoint:

bioaccumulation in aquatic species, other

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Remarks:

Internationally accepted method, EPI Suite, EPA (USA)

Justification for type of information:

See attached the QMRF and QPRF for the QSAR model.

Principles of method if other than guideline:

Calculation by EPI Suite, EPA (USA) v4.1 / BCFBAF v3.01

GLP compliance:

no

Key result

Type:

BCF

Value:

3.162 L/kg

Remarks on result:

other: (Log BCF from regression-based method = 0.500. log Kow used: 0.63)

The BCF of butanone oxime was 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).

Validity criteria fulfilled:

not applicable

Conclusions:

The BCF of butanone oxime was 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).

Executive summary:

Using the BCFBAF v3.01model of EPI Suite v4.1, the BCF of butanone oxime was 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).

Description of key information

Key study: Read-across from experimental data on analogue butanone oxime: Butan-2-one O,O',O''-(vinylsilanetriyl)oxime was determined to have a low bioconcentration potential.

Supporting study: Using the BCFBAF v3.01model of EPI Suite v4.1, the BCF of butanone oxime was 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).

Additional information

Key study: Read-across from analogue substance butanone oxime:

Based on published experimental data on analogue butanone oxime, where a bioaccumulation test in carp fish was performed by MITI (biocconcentration factor of (0.5)-(0.6) and <2.5 -(5.8) at a concentrations of 2 ppm and 0.2 ppm respectively), the read-across was applied and butan-2-one O,O',O''-(vinylsilanetriyl)oxime was determined to have a low bioconcentration potential.

 

Supporting studies:

Using the BCFBAF v3.01model of EPI Suite v4.1, the BCF of butanone oxime was 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).

 

It should be also taken into accoun that the substance undergoes rapid hydrolysis (half-life < 1h) in aqueous to 2-butanone oxime and vinylsilanetriol. The estimated log octanol-water partition coefficients (Log Kow) for the degradation products, 2 -butanone oxime and vinylsilanetriol were estimated to be 1.69 and -2.01 (EPI-Suite, KOWWIN v1.68). According to Verschueren et al (2009) the Log Kow of 2 -butanone oxime was reported to be 0.36. Morevoer, the corresponding silanols undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable.

 

Based on the available information, the test item is determined to have low bioconcentration potential based on the properties of its degradation products.