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EC number: 218-747-8 | CAS number: 2224-33-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 Nov 1986 - 22 Nov 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was conducted according to an appropriate OECD test guideline with acceptable restrictions. The restriction was a shorter observation time (reversibility of effects not fully assessable) than stated in the guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted 1981
- Deviations:
- yes
- Remarks:
- shorter observation period than specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Butan-2-one O,O',O''-(vinylsilylidyne)trioxime
- EC Number:
- 218-747-8
- EC Name:
- Butan-2-one O,O',O''-(vinylsilylidyne)trioxime
- Cas Number:
- 2224-33-1
- Molecular formula:
- C14H27N3O3Si
- IUPAC Name:
- N-[Bis[[(E)-butan-2-ylideneamino]oxy]-ethenylsilyl]oxybutan-2-imine
- Details on test material:
- - Name of test material (as cited in study report): Catalyseur 30 532 - Vinyltris (methylethylcetiminoxy) silane
- Substance type: Alkoxysilane
- Physical state: liquid
- Storage condition of test material: minimum 19°C
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Saint Aubin les Elbeuf, 76410 Cleon, France
- Weight at study initiation: 2.5 ± 0.2 kg
- Housing: individually, in polystyrene cages
- Diet: rabbit complete pelleted maintenance food (U.A.R. formula "112", U.A.R., Villemoisson Sur Orge, 91360 Epinay Sur Orge, France), ad libitum
- Water: softened and filtered drinking water, ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±3
- Humidity (%): 30-70
- Air changes (per hr): no data
- Photoperiod: 12 hrs dark / 12 hrs light
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 ml
- Concentration: 100% - Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h (the protocol describes examinations up to 14 days, but no observations are reported later than 72 h)
Reading time points: 1, 24, 48, 72 h - Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm²
- Type of wrap if used: Covered with a Codex hydrophilic eight layer gauze patch kept in contact with the skin by a wide perforated tape applied on a crimped gauze bandage.
REMOVAL OF TEST SUBSTANCE
- Washing: no data
- Time after start of exposure: After 4 hours the bandage was removed.
SCORING SYSTEM: Draize scheme
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- out of 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- out of 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
Any other information on results incl. tables
Table 1: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test.
Score at time point / Reversibility |
Erythema |
Edema |
Max. score: 4 |
Max. score: 4 |
|
60 min |
1/1/1/1/1/1 |
0/0/0/0/0/0 |
24 h |
0/1/1/1/1/1 |
0/0/0/0/0/0 |
48 h |
0/0/1/1/1/1 |
0/0/0/0/0/0 |
72 h |
0/0d/1d/1d/1d/1d |
0/0/0/0/0/0 |
Average 24h, 48h, 72h |
0.7 |
0 |
Reversibility by 72 h* |
n |
- |
* Reversibility: c = completely reversible; n.c.= not completely reversible; n = not reversible
d = desquamation
Applicant's summary and conclusion
- Interpretation of results:
- other: Non irritating (according to CLP regulation)
- Conclusions:
- A reliable study conducted broadly in accordance with OECD 404 and GLP, found the test material to be non- irritating to the skin of rabbits. Mild erythema remained in some animals the end of the short observation period (72 h), but no oedema was reported at any time point.
- Executive summary:
An acute dermal irritation/corrosion test was conducted in accordance with OECD 404 and GLP. The substance butan-2-one O,O',O''-(vinylsilanetriyl)oxime was found to be non-irritating to the skin of rabbits. Mild erythema (score of 0.7, mean 24 -72, 6 animals) remained in some animals at the end of the short observation period (72 h) but no oedemas was observed (score of 0).
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