Butan-2-one O,O',O''-(vinylsilylidyne)trioxime

Biodegradation in water: screening tests

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1992

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

Test method according to OECD TG 301 C. No data on GLP.

Qualifier:

according to guideline

Guideline:

OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))

GLP compliance:

not specified

Oxygen conditions:

aerobic

Inoculum or test system:

activated sludge (adaptation not specified)

Details on inoculum:

- Concentration of sludge: 30 mg/L

Duration of test (contact time):

28 d

Initial conc.:

100 mg/L

Based on:

test mat.

Parameter followed for biodegradation estimation:

TOC removal

Key result

Parameter:

other: BOD (NO2)

Value:

20

Sampling time:

28 d

Key result

Parameter:

other: BOD (NH3)

Value:

26

Sampling time:

28 d

Key result

Parameter:

% degradation (TOC removal)

Value:

28

Sampling time:

28 d

The test substance was hydrolyzed to form 2-Butanone oxime(2-0546, persistence, Low-Bioconcentration), Monomethylsilanol, and polymer (Polysiloxane) of the Monomethylsilanol. Analysis of the test substance was difficult.

Degradation % results were:

Indirect analysis	BOD (NO2)	BOD (NH3)
	28, 9, 24	36, 12, 31

 

Direct analysis	TOC
	34, 20, 31

 

Validity criteria fulfilled:

not specified

Interpretation of results:

under test conditions no biodegradation observed

Conclusions:

The test substance butan-2-one O,O',O''-(methylsilylidyne)trioxime was determined to be not readily biodegradable under test conditions.

Executive summary:

The readily biodegradation test was performed by MITI according to OECD Guideline 301 C. 30 mg/L of activated sludge were exposed for 28 days to 100 mg/L of test item butan-2-one O,O',O''-(methylsilylidyne)trioxime. The biodegradation was analysed by indirect analysis, BOD (NO2) and BOD (NH3) obtaining a biodegradation of 20% and 26% respectively and by direct TOC analysis obtaining a biodegradation of 28%. The test substance was determined to be not readily biodegradable under test conditions.

The test substance was hydrolyzed to form 2-Butanone oxime (2-0546, persistence, Low-Bioconcentration), Monomethylsilanol, and polymer (Polysiloxane) of the Monomethylsilanol. Analysis of the test substance was difficult.

Reference 2

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Remarks:

Internationally accepted method, EPI-Suite, EPA (USA)

Justification for type of information:

See attached the QMRF and QPRF for the QSAR model.

Principles of method if other than guideline:

Calculation by EPI-Suite, EPA (USA) / BIOWIN v4.10

GLP compliance:

no

The substances butan-2-one O,O',O''-(vinylsilanetriyl)oxime is predicted not to be readily biodegradable by EPI-Suite, EPA (USA) / BIOWIN v4.10.

Validity criteria fulfilled:

not applicable

Interpretation of results:

under test conditions no biodegradation observed

Conclusions:

The substances butan-2-one O,O',O''-(vinylsilanetriyl)oxime is predicted not to be readily biodegradable by EPI-Suite, EPA (USA) / BIOWIN v4.10 calculation method.

Executive summary:

The substances butan-2-one O,O',O''-(vinylsilanetriyl)oxime is predicted not to be readily biodegradable by EPI-Suite, EPA (USA) / BIOWIN v4.10 calculation method.

Reference 3

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue Butan-2-one O,O',O''-(methylsilanetriyl)oxime which shares the same functional group with Butan-2-one O,O',O''-(vinylsilanetriyl)oxime, also has comparable values for the relevant molecular properties for biodegradation.
See attached the reporting format.

Reason / purpose for cross-reference:

read-across source

Key result

Parameter:

other: BOD (NO2)

Value:

20

Sampling time:

28 d

Remarks on result:

other: (Results based on analogue substance butan-2-one O,O',O''-(methylsilanetriyl)oxime)

Key result

Parameter:

other: (NH3)

Value:

26

Sampling time:

28 d

Remarks on result:

other: (Results based on analogue substance butan-2-one O,O',O''-(methylsilanetriyl)oxime)

Key result

Parameter:

% degradation (TOC removal)

Value:

28

Sampling time:

28 d

Remarks on result:

other: (Results based on analogue substance butan-2-one O,O',O''-(methylsilanetriyl)oxime)

Details on results:

The analogue substance butan-2-one O,O',O''-(methylsilanetriyl)oxime was hydrolyzed to form 2-Butanone oxime(2-0546, persistence, Low-Bioconcentration), Monomethylsilanol, and polymer (Polysiloxane) of the Monomethylsilanol. Analysis of the test substance was difficult. Based on these results the test item butan-2-one O,O',O''-(vinylsilanetriyl)oxime is also expected to hydrolyse to form 2-butanoe oxime and the corresponding silanol and polysiloxane.

Validity criteria fulfilled:

not specified

Interpretation of results:

under test conditions no biodegradation observed

Conclusions:

Based on the read-across approach from experimental results on analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime, the test item butan-2-one O,O',O''-(vinylsilylidyne)trioxime was determined to be not readily biodegradable.

Executive summary:

The readily biodegradation test was performed by MITI according to OECD Guideline 301 C on analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime. 30 mg/L of activated sludge were exposed for 28 days to 100 mg/L. The biodegradation was analysed by indirect analysis, BOD (NO2) and BOD (NH3) obtaining a biodegradation of 20% and 26% respectively and by direct TOC analysis obtaining a biodegradation of 28%. Based on these results, the read-across was applied and the test item butan-2-one O,O',O''-(vinylsilylidyne)trioxime was determined to be not readily biodegradable under test conditions.

Description of key information

Key study: Based on the read-across approach from experimental results (test method OECD 301C) on the analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime, butan-2-one O,O',O''-(vinylsilylidyne)trioxime was determined to be not readily biodegradable.

Supporting study: EPI-Suite v4.1 (BIOWIN): Butan-2-one O,O',O''-(vinylsilanetriyl)oxime was predicted to not readily biodegradable.

Key value for chemical safety assessment

Biodegradation in water:

under test conditions no biodegradation observed

Additional information

Key study: Read-across from experimental data on analogue butan-2-one O,O',O''-(methylsilanetriyl)oxime:

A readily biodegradation test was performed by MITI according to OECD Guideline 301 C on analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime. 30 mg/L of activated sludge were exposed for 28 days to 100 mg/L. The biodegradation was analysed by indirect analysis, BOD (NO2) and BOD (NH3) obtaining a biodegradation of 20% and 26% respectively and by direct TOC analysis obtaining a biodegradation of 28%. Based on these results, the read-across was applied and the test item butan-2-one O,O',O''-(vinylsilylidyne)trioxime was determined to be not readily biodegradable under test conditions.

Supporting study: According the the calculation method EPI-Suite, EPA (USA) / BIOWIN v4.10, butan-2-one O,O',O''-(vinylsilanetriyl)oxime was predicted to not readily biodegradable.