Registration Dossier
Registration Dossier
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EC number: 202-784-1 | CAS number: 99-75-2
Stability in organic solvents and identity of relevant degradation products
Administrative data
- Endpoint:
- stability in organic solvents and identity of relevant degradation products
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well performed study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: company SOP
- Principles of method if other than guideline:
- 72 hours stirring in DMSO and ethanol (0.1 and 50 mg/ml) at room temperature. Dilution with methanol for detection of test substance by HPLC.
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl p-toluate
- EC Number:
- 202-784-1
- EC Name:
- Methyl p-toluate
- Cas Number:
- 99-75-2
- Molecular formula:
- C9H10O2
- IUPAC Name:
- methyl 4-methylbenzoate
- Details on test material:
- purity: 97.8 %
Constituent 1
Results and discussion
- Test substance stable:
- yes
- Transformation products:
- no
Applicant's summary and conclusion
- Conclusions:
- The test substance is stable and homogeneous for more than 72 hours in DMSO (0.1 and 50 mg/ml) and in ethanol (0.1 and 50 mg/ml) at room temperature.
- Executive summary:
The stability of the substance in DMSO and ethanol was tested by stirring it in these solvents at room temperature in concentrations of 0.1 mg/L and 50 mg/L. After dilution with methanol, the concentrations were determined by HPLC. It was found that the substance is stable under these conditions.
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