Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
IUCLID Dataset Substance ID: 99-75-2
Author:
IUCLID
Year:
2000
Bibliographic source:
http://esis.jrc.ec.europa.eu/ with reference to Montefibre S.p.A
Report Date:
2000
Reference Type:
secondary source
Title:
Fragrance raw materials monographs. Methyl p-toluate
Author:
Opdyke DLJ
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology, Vol. 17 Suppl. 183-184
Report Date:
1979

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
48-h closed patch test
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
8 % of test substance in petrolatum

Method

Subjects:
no data
Route of exposure:
dermal
Reason of exposure:
intentional
Exposure assessment:
not specified

Results and discussion

Clinical signs:
No irritation was observed after 48 h of occlusive exposure

Applicant's summary and conclusion

Conclusions:
In this 48-h closed patch test the test substance (8 % in petrolatum) was not irritating to human skin.