Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
IUCLID Dataset Substance ID: 99-75-2
Author:
IUCLID
Year:
2000
Bibliographic source:
http://esis.jrc.ec.europa.eu/ with reference to Montefibre S.p.A
Report Date:
2000
Reference Type:
secondary source
Title:
Fragrance raw materials monographs. Methyl p-toluate
Author:
Opdyke DLJ
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology, Vol. 17 Suppl. 183-184
Report Date:
1979

Materials and methods

Principles of method if other than guideline:
Skin irritation test
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact or abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Duration of treatment / exposure:
24 h
Observation period:
no data
Number of animals:
no data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
other: no data
Remarks on result:
other: moderately irritating

Applicant's summary and conclusion

Conclusions:
Under the conditions of this study the test substance was moderately irritating (applikation to intact or abraded rabbit skin for 24 hours under occlusion).