Registration Dossier

Administrative data

Endpoint:
epidemiological data
Type of information:
other:
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1962
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
IUCLID Dataset Substance ID: 99-75-2
Author:
IUCLID
Year:
2000
Bibliographic source:
http://esis.jrc.ec.europa.eu/ with reference to Montefibre S.p.A
Report Date:
2000
Reference Type:
secondary source
Title:
Fragrance raw materials monographs. Methyl p-toluate
Author:
Opdyke DLJ
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology, Vol. 17 Suppl. 183-184
Report Date:
1979

Materials and methods

Study type:
other: workplace experience, not further specified
Endpoint addressed:
repeated dose toxicity: inhalation
Principles of method if other than guideline:
Occupational health study
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: vapour
Details on test material:
no data

Method

Details on study design:
no data
Exposure assessment:
not specified

Results and discussion

Results:
Workers exposed to methyl-p-toluate, among other substances, were reported to have shown moderate leucocytosis at the extense of neutrophils in several cases
Confounding factors:
other, unknown substances

Applicant's summary and conclusion

Conclusions:
No definite conclusions can be drawn from this study due to the presence of other, unknown substances at the workplace.