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EC number: 202-784-1 | CAS number: 99-75-2
Reported oral LD50 values are 3300 mg/kg bw in rats, and 3800 mg/kg bw in mice. An ester mixture with 26 % submission substance showed an oral LD50 of 2987 mg/kg bw in rats.For the inhalation route the LC50 in rats was above 0.49 mg/L, the highest concentration tested. A lethal concentration (40-60 % mortality) of 0.040-0.070 mg/L was reported in mice.No mortality was observed after dermal exposure of rabbits to 5000 mg/kg bw. Therefore the LD50 is above 5000 mg/kg bw.
Reported oral LD50 values are 3300 mg/kg bw in rats (US EPA HPV, 2001, RL4), and 3800 mg/kg bw in mice (IUCLID, 2000; RL4). An ester mixture with 26 % submission substance showed an oral LD50 of 2987 mg/kg bw in rats (Haskell, 1981; RL3).
The available information is not reliable: Hoechst (1982) reported no mortality at a concentration of 0.49 mg/L. The study is reliable with respect to conceptual design and documentation, but the exposure concentration is too low for definite conclusions on classification.
The other information from secondary source only is a lethal concentration in mice (40 -60 % mortality) of 0.04 -0.070 mg/L. No details are provided. This is in clear contrast to the result of the well-performed study by Hoechst (1982), where no mortality was observed in rats at a 7 -12 fold higher concentration. A species-specific sensitivity difference of this magnitude is not plausible. Therefore, the effects in mice are disregarded.
The available study were rabbits were exposed topically to the test item reported no mortality at a dermal exposure of 5000 mg/kg bw (US EPA HPV, 2001). Though formally as secondary source not assignable, the result was considered to be reliable by the submitters of the report to the US EPA. Therefore no classification for acute dermal toxicity is necessary.
Based on the available information, the submission substance has not to be classified with respect to oral and dermal exposure (CLP (Regulation (EC) No 1272/2008) and DSD-DPD (Council Directive 67/548/EEC)). No reliable data are available for inhalation exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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