Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 204-409-7 | CAS number: 120-57-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 February 2013 – 28 February 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP compliant study in compliance with international recognized guidelines.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 1.1 g/L
- Temp.:
- 10 °C
- pH:
- > 5 - < 6.9
- Remarks on result:
- other: standard deviation: 0.026, replicates of three days
- Water solubility:
- 1.4 g/L
- Temp.:
- 20 °C
- pH:
- > 4.8 - < 5.8
- Remarks on result:
- other: standard deviation: 0.008, replicates of three days
- Details on results:
- The difference between the concentrations of the test substance of day 1 to 3 at 10 °C and 20 °C was <15 % and the concentrations of the test substance showed no relevant tendency. Therefore the mean of day 1 - 3 was taken as the solubility of the test substance at both temperatures, according to the guidelines.
As the temperature coefficient of the solubility of the test substance was <3 % (i.e. 2.8 %) per °C, the solubility was not determined at three temperatures, in agreement with the guideline. - Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The water solubility of the test substance is 1.4 ± 0.008 g/L at 20ºC. - Executive summary:
Following the flask method detailed within OECD 105, the solubility of the test substance was determined to be 1.4 ± 0.008 g/L (1400 mg/L) at 20ºC based on the mean of day 1 – 3. As the temperature coefficient of the solubility of the test substance was <3% (i.e. 2.8%) per ºC, the solubility was not determined at three temperatures.
Reference
Description of key information
The water solubility of the test substance is 1.4 ± 0.008 g/L at 20ºC.
Key value for chemical safety assessment
- Water solubility:
- 1 400 mg/L
- at the temperature of:
- 20 °C
Additional information
Following the flask method detailed within OECD 105, the solubility of the test substance was determined to be 1.4 ± 0.008 g/L (1400 mg/L) at 20ºC based on the mean of day 1 – 3. As the temperature coefficient of the solubility of the test substance was <3% (i.e. 2.8%) per ºC, the solubility was not determined at three temperatures.
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