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EC number: 482-410-3 | CAS number: -
Following a preliminary screening test in which no clinical signs of toxicity were noted at a concentration of 100%, this concentration was selected as the highest dose investigated in the main test of the Local Lymph Node Assay. Three groups, each of five animals, were treated with 50 µl (25 µl per ear) of the undiluted test material or the test material as asolutioninacetone/olive oil 4:1at concentrations of 50% or 25% v/v. A further group of five animals was treated withacetone/olive oil 4:1alone.
Results. The Stimulation Index expressed as the mean radioactive incorporation for each treatment group divided by the mean radioactive incorporation of the vehicle control group are as follows:
Concentration (%v/v) inacetone/olive oil 4:1
Conclusion. The test material was considered to be a non‑sensitiser under the conditions of the test.
The above study had been ranked reliability 1 according to the scoring system of Klimish at al. This ranking was deemed appropriate because the study was conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.
The test material did not meet the criteria for classification as a skin sensitiser under the condition of the test.
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