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EC number: 258-548-3
CAS number: 53423-65-7
mean revertant colony counts for each strain treated with the vehicle
were close to or within the expected range, considering the laboratory
historical control range and/or published values (Mortelmans & Zeiger,
2000; Gatehouse, 2012). The
positive control substances caused the expected substantial increases in
revertant colony counts in both the absence and presence of S9 in each
phase of the test confirming the sensitivity of the test and the
activity of the S9 mix. Therefore,
each phase of the test is considered valid.
signs of precipitation were noted in any of the strains. Contamination
which did not obscure counts was seen for TA1537 at dose 5000 µg/plate
with S9 in the pre-incubation method. Contamination did not affect
mutagenic evaluation. For all strains, at least eight non-toxic doses
were evaluated; hence bacterial mutagenicity was adequately assessed.
was no concentration-related or substantial test substance related
increases in the number of revertant colonies observed with strains
TA1535, TA1537, TA98 , TA100 or E. coli WP2 uvrA in both the absence and
presence of S9 using either the plate incorporation or the
In a GLP guideline bacterial reverse
mutation assay using the plate incorporation and pre-incubation methods
conducted according to OPPTS 870.5100, OECD 471, and EC method B.13/14,
the substance did not elicit evidence of bacterial mutagenic activity
with or without rat liver S9 metabolic activation with
strains TA1535, TA1537, TA98 , TA100 or E. coli WP2 uvrA.
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