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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 Feb 18 - 17 April 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
no
GLP compliance:
yes
Specific details on test material used for the study:
CAS#: 53423-65-7
EC#: 258-548-3
Label Identification: Arichem, LLC; 187 Sloss Industries Road; Ariton, AL 36311 USA
Product Sample: Sodium Trichlorobenzene Sulfonate
Lot: 1708-09; Approx 100g
Date & Quantity Received: 29 Jan 18; 109.7 g (GW)
Physical Description: White powder
Storage Conditions: Room temperature
Purity: 100% active ingredient, refer to the Sponsor provided Certificate of Analysis
Analytical monitoring:
no
Remarks:
Substance is a non-volatile solid and known to be stable in water at environmetal pH
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
Test Room: Environmentally controlled chamber A
Test Chambers: 250 mL glass beakers; filled with 200 mL of the appropriate solution
Test Medium: Moderately hard synthetic freshwater:
Holding: Before dosing, the daphnids were held in water of the quality used in the test.
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
48 h
Hardness:
Range-finding: 215 mg/L CaCO3
Limit Test: 180 mg/L CaCO3
Test temperature:
Target: 20 ± 1°C
Actual: 21 °C
pH:
Range-finding: 7.8
Limit Test: 7.4
Dissolved oxygen:
Range-finding: 83-93%
Limit Test: 91-95%
Conductivity:
652 - 687 µmhos/cm
Nominal and measured concentrations:
Range-finding: 0.01 mg/L, 0.1 mg/L, 1.0 mg/L, 10 mg/L, and 100 mg/L
Limit Test: 100 mg/L
Reference substance (positive control):
no
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Details on results:
All organisms were mobile at the end of the study and thus the EC50 was determined to be >100 mg/L.

Limit Test Survival:

Conc.

(mg/L)

Replicate

Number of Surviving Organisms

Survival

0 Hours

24 Hours

48 Hours

Control

A

5

5

5

100%

B

5

5

5

C

5

5

5

D

5

5

5

100

A

5

5

5

100%

B

5

5

5

C

5

5

5

D

5

5

5

Note:All organisms had no observable abnormalities unless otherwise indicated.

Validity criteria fulfilled:
yes
Conclusions:
The EC50 was determined to be >100 mg/L.
Executive summary:

In a GLP guidline study conducted according to OECD 202, the substance was evaluated for toxicity to Daphnia Magna in a 48-hour static test at a limit dose of 100 mg/L. All test organisms (100%) survived the 48 -hour test period. Given these results, the EC50 was determined to be >100 mg/L.

Description of key information

In a GLP guidline study conducted according to OECD 202, the substance was evaluated for toxicity toDaphnia Magnain a 48-hour static test at a limit dose of 100 mg/L. All test organisms (100%) survived the 48 -hour test period. Given these results, the EC50 was determined to be >100 mg/L.

Key value for chemical safety assessment

Additional information

The EC50 was determined to be >100 mg/L.

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