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EC number: 258-548-3 | CAS number: 53423-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 16 – December 11, 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: OPPTS 830.7840, OECD TG 105, and EEC Test Method A6
- Deviations:
- yes
- Remarks:
- Insoluble portion determed by use of centrifuge, drying, and gravimetric analysis
- Principles of method if other than guideline:
- The solubility of the test substance in n-octanol was performed by the shake-flask method, according to OPPTS 830.7840, OECD TG 105, and EEC Test Method A6.
Once each day for three consecutive days, saturated solutions of the test substance in n-octanol were prepared. On Days 1 and 3, three solutions were prepared by weighing approximately 2 grams of test substance into separate vessels and 35 mL of n-octanol was added. The solutions were then vortexed for 120 minutes. On Day 2, five solutions were prepared using the above method.
After each preparation, the flasks were tightly stoppered, then placed into a water bath and agitated at a temperature of 30°C. The first set of prepared flasks was agitated for three days; the second set and third set flask were agitated two days and one day, respectively. The start times were staggered, so all flasks would be ready for gravimetric analysis on the same day. After this time, the flasks were removed from the water bath and re-equilibrated at the test temperature of 20°C for an additional 24 hours with occasional shaking. Two blank samples (octanol only) were prepared and tested using the above procedure. After the appropriate agitation and re-equilibration time periods, each centrifuge tube was spun at 3000 rpm for ~ 60 minutes. After centrifugation, the upper aqueous solution was filtered through a Gooch crucible containing glass fiber paper (previously dried at 100ºC for approximately 2 hours and pre-weighed) with the aid of a vacuum pump filtering device into another pre-weighed centrifuge tube. The crucible containing the filter paper was dried for 24 hours and the initial centrifuge tubes containing the pellets were dried for 48 hours at 100-105ºC to a consistent weight and then allowed to cool to room temperature. The weight of the residual test substance in each vessel (in centrifuge tube and on filter paper) was recorded after drying. The amount of test substance dissolving in n-octanol was determined by subtracting the concentration (g/L) of the non-soluble portion from the starting concentration (g/L). - GLP compliance:
- yes
- Specific details on test material used for the study:
- Composition: Benzenesulfonic acid, 2,4,5-trichloro-, sodium salt – 100%
CAS# 53423-65-7
EC# 258-548-3
Physical Description: White powder
Stability: Test substance was expected to be stable for the duration of testing.
Expiration Date: December 31, 2018 - Key result
- Medium:
- n-octanol
- Solubility:
- 0 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Solubility reported as -1.08 g/L
- Test substance stable:
- yes
- Conclusions:
- The substance is insoluble in n-Octanol.
- Executive summary:
In a GLP study according to the Shake Flask method procedures described for water solubility in OPPTS 830.7840, OECD TG 105, and EC Test Method A6, the solubility of the test substance in n-Octanol was determined to be -1.08 g/L and thus insoluble in n-Octanol.
Reference
Wt. of Non-Soluble TS Retained in Tube (g) |
Wt. of Non-Soluble TS in Crucible (g) |
Non-Soluble Portion of Test Substance |
Octanol Solubility |
|||||||||||
Tube # |
Spl. Wt. (g) (dried) |
Empty Tube Wt. (g) |
Wt. of Tube + Non-Soluble TS After Drying (g) |
Wt. of Non-Soluble TS (g) |
Crucible # |
Empty Crucible Wt. (g) |
Crucible + TS (g) |
Wt. of TS. in Crucible |
g |
g/L |
g/L |
SD (%) |
Avg. (g/L) |
g/1000 mL |
1 |
2.0330 |
10.5860 |
12.6008 |
2.0148 |
1 |
30.2797 |
30.2800 |
0.0003 |
2.0151 |
991.2 |
999.10 |
1001.08 |
3.25 |
-1.08[1] |
2 |
2.0979 |
10.4966 |
12.5940 |
2.0974 |
2 |
30.4448 |
30.4458 |
0.0010 |
2.0984 |
1000.2 |
||||
3 |
2.4999 |
10.5566 |
13.0553 |
2.4987 |
3 |
31.4327 |
31.4487 |
0.0160 |
2.5147 |
1005.9 |
||||
4 |
2.0625 |
10.5380 |
12.6002 |
2.0622 |
4 |
30.5756 |
30.5935 |
0.0179 |
2.0801 |
1008.5 |
1003.70 |
|||
5 |
2.0302 |
10.5867 |
12.6160 |
2.0293 |
5 |
29.9701 |
29.982 |
0.0119 |
2.0412 |
1005.4 |
||||
6 |
2.1157 |
10.4971 |
12.6120 |
2.1149 |
6 |
29.9054 |
29.9162 |
0.0108 |
2.1257 |
1004.7 |
||||
7 |
2.0354 |
10.4621 |
12.4960 |
2.0339 |
7 |
30.4374 |
30.439 |
0.0016 |
2.0355 |
1000.0 |
||||
8 |
2.0357 |
10.3321 |
12.3668 |
2.0347 |
8 |
30.2758 |
30.2765 |
0.0007 |
2.0354 |
999.9 |
||||
9 |
2.1249 |
10.5145 |
12.6383 |
2.1238 |
9 |
31.2240 |
31.2261 |
0.0021 |
2.1259 |
1000.5 |
1000.43 |
|||
10 |
2.0333 |
10.5523 |
12.5848 |
2.0325 |
10 |
30.4033 |
30.4051 |
0.0018 |
2.0343 |
1000.5 |
||||
11 |
2.0378 |
10.5144 |
12.5514 |
2.0370 |
11 |
29.3395 |
29.341 |
0.0015 |
2.0385 |
1000.3 |
1The test substance is insoluble in octanol.
Description of key information
The substance is insoluble in n-Octanol.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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