Sodium 2,4,5-trichlorobenzenesulphonate

Genetic toxicity: in vivo

Administrative data

Endpoint:

in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration

Type of information:

experimental study planned

Justification for type of information:

TESTING PROPOSAL ON VERTEBRATE ANIMALS

NON-CONFIDENTIAL NAME OF SUBSTANCE:
- sodium 2,4,5-trichlorobenzenesulphonate

CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION
- Available GLP studies: none available
- Available non-GLP studies: none available
- Historical human/control data: none available
- (Q)SAR: Registrant is considering options for valid (Q)SAR models
- In vitro methods: substance was positive (+) in vitro for chrom. abb.
- Weight of evidence: none available
- Grouping and read-across: none available
- Substance-tailored exposure driven testing: not applicable
- Approaches in addition to above: not applicable

CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- There are no Column 2 adaptations that can be applied.

FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
- An OECD 474 / EC B.12 Micronucleous test in rats is proposed.

Materials and methods

Test guideline

Guideline:

OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

Sodium 2,4,5-trichlorobenzenesulphonate

EC Number:

258-548-3

EC Name:

Sodium 2,4,5-trichlorobenzenesulphonate

Cas Number:

53423-65-7

Molecular formula:

C6H2Cl3O3S.Na

IUPAC Name:

sodium 2,4,5-trichlorobenzenesulfonate

Test material form:

solid: particulate/powder

Test animals

Species:

rat