Registration Dossier
Registration Dossier
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EC number: 258-548-3 | CAS number: 53423-65-7
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Type of information:
- experimental study planned
- Justification for type of information:
- TESTING PROPOSAL ON VERTEBRATE ANIMALS
NON-CONFIDENTIAL NAME OF SUBSTANCE:
- sodium 2,4,5-trichlorobenzenesulphonate
CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION
- Available GLP studies: none available
- Available non-GLP studies: none available
- Historical human/control data: none available
- (Q)SAR: Registrant is considering options for valid (Q)SAR models
- In vitro methods: substance was positive (+) in vitro for chrom. abb.
- Weight of evidence: none available
- Grouping and read-across: none available
- Substance-tailored exposure driven testing: not applicable
- Approaches in addition to above: not applicable
CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- There are no Column 2 adaptations that can be applied.
FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
- An OECD 474 / EC B.12 Micronucleous test in rats is proposed.
Data source
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Sodium 2,4,5-trichlorobenzenesulphonate
- EC Number:
- 258-548-3
- EC Name:
- Sodium 2,4,5-trichlorobenzenesulphonate
- Cas Number:
- 53423-65-7
- Molecular formula:
- C6H2Cl3O3S.Na
- IUPAC Name:
- sodium 2,4,5-trichlorobenzenesulfonate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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