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Hydrolysis

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] can be expected to be 47 and 5.1 days at pH 7.0 and 9.0 & at a temperature of 25⁰C, respectively and it was reported to be hydrolytically stable at pH 4 or 55 days, 5.3 days and 13 hrs at pH 8, 9 & 10, respectively iwth a second order hydrolysis rate constant of 0.15L/mol-sec, respectively. Thus, based on this half-life value, it can be concluded that the test chemical 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] is not hydrolysable.

Additional information

Hydrolysis

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical 1,4-phenylene bis[(4-phenoxyphenyl)-methan one] (CAS no. 54299 -17 -1). The studies are as mentioned below:

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C and pH of 4, 7 and 9, respectively. The half-life period of test chemical was determined to be 47 and 5.1 days at pH 7.0 and 9.0, respectively and it was reported to be hydrolytically stable at pH 4 & at a temperature of 25⁰C. On the basis of this, test chemical is considered to be not hydrolysable.

The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.15L/mol-sec with a corresponding half-lives of 55 days, 5.3 days and 13 hrs at pH 8, 9 and 10, respectively. Based on the half-life value (55 days at pH 8.0), it is concluded that the test chemical is not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] can be expected to be 47 and 5.1 days at pH 7.0 and 9.0 & at a temperature of 25⁰C, respectively and it was reported to be hydrolytically stable at pH 4 or 55 days, 5.3 days and 13 hrs at pH 8, 9 & 10, respectively iwth a second order hydrolysis rate constant of 0.15L/mol-sec, respectively. Thus, based on this half-life value, it can be concluded that the test chemical 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] is not hydrolysable.