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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Reference
Reference Type:
other: authoritative database
Title:
Acute oral toxicity study in Rat.
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity of test chemical in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: 2,2-Bis[4-(4-aminophenoxy)phenyl]hexafluoropropane
- InChI: 1S/C27H20F6N2O2/c28-26(29,30)25(27(31,32)33,17-1-9-21(10-2-17)36-23-13-5-19(34)6-14-23)18-3-11-22(12-4-18)37-24-15-7-20(35)8-16-24/h1-16H,34-35H2
- Smiles: C(C(F)(F)F)(C(F)(F)F)(c1ccc(Oc2ccc(cc2)N)cc1)c1ccc(Oc2ccc(cc2)N)cc1
- Molecular formula :C27H20F6N2O2
- Molecular weight :518.455 g/mol
- Substance type:Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
1340 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
- Other examinations performed: Animals were observed for clinical signs.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 340 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed in treated rats.
Clinical signs:
Changes in liver were observed.
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The acute oral LD50 value was considered to be 1340 mg/kg bw, when rats were treated with test chemical via oral route.
Executive summary:

Acute oral toxicity study of test chemical was conducted in rats at the dose concentration of 1340 mg/kg bw. Animals were observed for clinical signs. 50% mortality was observed in treated rats. Changes in liver were observed. Hence, LD50 value was considered to be 1340 mg/kg bw, when rats were treated with test chemical via oral route.